He is the second top Republican lawmaker in the Congress to have announced his retirement, which some media outlets said is an indication of a Democratic wave for the upcoming November mid-term election. "Yet with the support of my family, I have decided that I will not seek re-election in California's 49th District", Issa explained in an official press statement.
On Tuesday, another Southern California Republican, Rep. Ed Royce, who chairs the Foreign Affairs Committee, announced he too would not run for reelection.
The politically charged investigation targeted Obama's secretary of state, Hillary Clinton, who at the time was considered the leading 2016 Democratic presidential candidate.
The Democratic Congressional Campaign Committee placed field organizers in Issa's district almost a near ago, and opened an Orange County office past year aimed at flipping the Issa and Royce seats to Democrats.
Representative Steve Stivers of OH, the chairman of the Republican campaign arm, predicted that a contentious Democratic primary would leave the eventual nominee "black and blue, and broke".
Yet another Republican congressman is choosing to retire rather than run for reelection, leaving the GOP's hold on the House of Representatives in further peril.
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